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Anti-P21 (WQ1) Antibody
品牌：Antibodies
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規(guī)格：50μl
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Anti-P21 (WQ1) Antibody
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Name: Anti-P21 (WQ1) Antibody
See all P21 primary antibodies
Description: Rabbit polyclonal antibody to P21 (WQ1)
Specificity: P21 (WQ1) pAb detects endogenous levels of P21 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse
Immunogen: Recombinant full length Human P21.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 21 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
Tissue Specificity: Expressed in all ***** tissues, with 5-fold lower levels observed in the brain.
Sequence Similarities: Belongs to the CDI family.
Post-Translational Modification: Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-145 by PIM2 enhances CDKN1A stability and inhibits cell proliferation. Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. UV radiation-induced phosphorylation at Thr-80 by LKB1 and at Ser-146 by NUAK1 leads to its degradation.
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 1026?Human
  • Entrez Gene: 12575?Mouse
  • Omim: 116899?Human
  • SwissProt: P38936?Human
  • SwissProt: P39689?Mouse
  • Unigene: 370771?Human
  • Unigene: 195663?Mouse
    		•
    Synonyms:
  • CAP20 Antibody
  • CDK-interacting protein 1 Antibody
  • CDKI Antibody
  • CDKN1 Antibody
  • Cdkn1a Antibody
  • CDN1A_HUMAN Antibody
  • CIP1 Antibody
  • Cyclin Dependent Kinase Inhibitor 1A Antibody
  • Cyclin-dependent kinase inhibitor 1 Antibody
  • Cyclin-dependent kinase inhibitor 1A (P21) Antibody
  • Cyclin-dependent kinase inhibitor 1A (p21, Cip1) Antibody
  • DNA Synthesis Inhibitor Antibody
  • MDA-6 Antibody
  • MDA6 Antibody
  • Melanoma differentiation-associated protein Antibody
  • Melanoma differentiation-associated protein 6 Antibody
  • p21 Antibody
  • P21 protein Antibody
  • p21CIP1 Antibody
  • p21Cip1/Waf1 Antibody
  • p21WAF Antibody
  • PIC1 Antibody
  • SDI1 Antibody
  • SLC12A9 Antibody
  • WAF1 Antibody
  • Wild type p53 activated fragment 1 Antibody
  • Wild type p53 activated fragment 1 (WAF1) Antibody
  • Wildtype p53-activated fragment 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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