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Anti-ELAVL1 Antibody
品牌：Antibodies
貨號：
規(guī)格：50μl
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Anti-ELAVL1 Antibody
商品詳情 參考文獻(xiàn) 相關(guān)資料
Name: Anti-ELAVL1 Antibody
See all ELAVL1 primary antibodies
Description: Rabbit polyclonal antibody to ELAVL1.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:100 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human ELAVL1.
Protein Length: 326
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).
Tissue Specificity: Ubiquitous. Detected in brain, liver, thymus and muscle.
Sequence Similarities: Belongs to the RRM elav family.
Post-Translational Modification: Phosphorylated by MAPKAPK2 (PubMed:14517288). Phosphorylated by PRKCD (PubMed:18285462).
Cellular Location: Cytoplasm. Nucleus.

Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288). Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462).
Database Links:
  • Entrez Gene: 1994?Human
  • Entrez Gene: 15568?Mouse
  • Entrez Gene: 363854?Rat
  • Omim: 603466?Human
  • SwissProt: Q15717?Human
  • SwissProt: P70372?Mouse
  • Unigene: 184492?Human
  • Unigene: 713744?Human
  • Unigene: 119162?Mouse
    		•
    Synonyms:
  • ELAV (embryonic lethal abnormal vision Drosophila) like 1 Antibody
  • ELAV (embryonic lethal, abnormal vision, Drosophila) like 1 (Hu antigen R) Antibody
  • ELAV like 1 Antibody
  • ELAV like RNA binding protein 1 Antibody
  • ELAV-like protein 1 Antibody
  • ELAV1 Antibody
  • ELAV1_HUMAN Antibody
  • Elavl1 Antibody
  • Embryonic lethal abnormal vision drosophila homolog like 1 Antibody
  • Hu Antigen R Antibody
  • Hu-antigen R Antibody
  • Hua Antibody
  • HuR Antibody
  • HuR / ELAVL1 Antibody
  • MelG Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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