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Anti-KPNA3 Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-KPNA3 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-KPNA3 Antibody See all KPNA3 primary antibodies
Description:	Goat polyclonal antibody to KPNA3.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human KPNA3 (C terminal).
Sequence:	C-DPTANLQTKEFNF
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.
Tissue Specificity:	Ubiquitous. Highest levels in heart and skeletal muscle.
Sequence Similarities:	Belongs to the importin alpha family.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 3839?Human Omim: 601892?Human SwissProt: O00505?Human Unigene: 527919?Human
Synonyms:	SRP1 gamma Antibody hSRP1 Antibody IMA4_HUMAN Antibody Importin alpha 3 Antibody Importin alpha 3 subunit Antibody Importin alpha 4 Antibody Importin alpha Q2 Antibody Importin subunit alpha-4 Antibody IPOA4 Antibody Karyopherin alpha 3 Antibody Karyopherin alpha 3 importin alpha 4 Antibody Karyopherin alpha 3 subunit Antibody Karyopherin subunit alpha 3 Antibody Karyopherin subunit alpha-3 Antibody KPNA 3 Antibody KPNA3 Antibody Qip2 Antibody SRP1 Antibody SRP1-gamma Antibody SRP1gamma Antibody SRP4 Antibody
Information:	Target information shown above is from the UniProt Consortium.