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Anti-TRAF6 (H154) Antibody

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規(guī)格：50μl

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Anti-TRAF6 (H154) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-TRAF6 (H154) Antibody See all TRAF6 primary antibodies
Description:	Rabbit polyclonal antibody to TRAF6 (H154)
Specificity:	TRAF6 (H154) pAb detects endogenous levels of TRAF6 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 122-170 of Human TRAF6.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 58 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
Tissue Specificity:	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Sequence Similarities:	Belongs to the TNF receptor-associated factor family. A subfamily.
Post-Translational Modification:	Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1.
Cellular Location:	Cytoplasm. Cytoplasm > Cell cortex. Nucleus. Lipid droplet. Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity).
Database Links:	Entrez Gene: 7189?Human Entrez Gene: 22034?Mouse Entrez Gene: 311245?Rat Omim: 602355?Human SwissProt: Q9Y4K3?Human SwissProt: P70196?Mouse SwissProt: B5DF45?Rat Unigene: 444172?Human Unigene: 591983?Human Unigene: 292729?Mouse Unigene: 220435?Rat
Synonyms:	E3 ubiquitin-protein ligase TRAF6 Antibody Interleukin 1 signal transducer Antibody Interleukin-1 signal transducer Antibody MGC 3310 Antibody MGC3310 Antibody MGC:3310 Antibody OTTHUMP00000232772 Antibody OTTHUMP00000232773 Antibody RING finger protein 85 Antibody RNF 85 Antibody RNF85 Antibody TNF receptor associated factor 6 Antibody TNF receptor-associated factor 6 Antibody TNF receptor-associated factor 6, E3 ubiquitin protein ligase Antibody TRAF 6 Antibody TRAF6 Antibody TRAF6_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.