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Anti-Ephrin-A5 (P63) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Ephrin-A5 (P63) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-Ephrin-A5 (P63) Antibody See all Ephrin-A5 primary antibodies
Description:	Rabbit polyclonal antibody to Ephrin-A5 (P63)
Specificity:	Ephrin-A5 (P63) pAb detects endogenous levels of Ephrin-A5 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 50-100 of Human Ephrin-A5.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 25 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
Sequence Similarities:	Belongs to the ephrin family.
Cellular Location:	Cell membrane. Membrane > Caveola. Compartmentalized in discrete caveolae-like membrane microdomains.
Database Links:	Entrez Gene: 1946?Human Entrez Gene: 13640?Mouse Entrez Gene: 116683?Rat Omim: 601535?Human SwissProt: P52803?Human SwissProt: O08543?Mouse SwissProt: P97605?Rat Unigene: 288741?Human Unigene: 401670?Mouse Unigene: 7978?Mouse Unigene: 10714?Rat
Synonyms:	EPLG7 Antibody AF1 Antibody AL 1 Antibody AL-1 Antibody EFL5 Antibody Efna5 Antibody EFNA5_HUMAN Antibody EPH-related receptor tyrosine kinase ligand 7 Antibody Ephrin A5 Antibody Ephrin-A5 Antibody EPLG7 Antibody GLC1M Antibody LERK-7 Antibody LERK7 Antibody RAGS Antibody
Information:	Target information shown above is from the UniProt Consortium.