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Anti-EPS8 Antibody

品牌：Antibodies

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Anti-EPS8 Antibody

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Overview

Name:	Anti-EPS8 Antibody See all EPS8 primary antibodies
Description:	Rabbit polyclonal antibody to EPS8
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide contain a sequence corresponding to a region within amino acids 761 and 822 of EPS8
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 1XPBS, 1%BSA, 20% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.
Tissue Specificity:	Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.
Involvement in Disease:	Deafness, autosomal recessive, 102: A form of non-syndromic deafness characterized by profound hearing loss affecting all frequencies. Vestibular function is unaffected.
Sequence Similarities:	Belongs to the EPS8 family.
Post-Translational Modification:	Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during G2 phase, leading to its transient degradation and subsequent cell shape changes required to allow mitotic progression. Reappears at the midzone of dividing cells (By similarity).
Cellular Location:	Cytoplasm > Cell cortex. Cell projection > Ruffle membrane. Cell projection > Growth cone. Cell projection > Stereocilium. Cell junction > Synapse > Synaptosome. Localizes at the tips of the stereocilia of the inner and outer hair cells (By similarity). Localizes to the midzone of dividing cells.
Database Links:	Entrez Gene: 2059?Human Omim: 600206?Human SwissProt: Q12929?Human Unigene: 591160?Human
Synonyms:	Epidermal growth factor receptor kinase substrate 8 Antibody Epidermal growth factor receptor pathway substrate 8 Antibody EPS 8 Antibody EPS8 Antibody EPS8_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.