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1-methyl-D-tryptophan(D-1MT),IDOInhibitor

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1-methyl-D-tryptophan(D-1MT),IDOInhibitor

品牌：Xcessbio

貨號(hào)：M60291-2s

規(guī)格：2 mg solid

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1-methyl-D-tryptophan(D-1MT),IDOInhibitor

商品詳情參考文獻(xiàn) 相關(guān)資料

Product Information

Molecular Weight:	218.25
Formula:	C₁₂H₁₄N₂O₂
Purity:	≥98%
CAS#:	110117-83-4
Solubility:	Water up to 5 mM (warming)
Chemical Name:	1-methyl-D-tryptophan
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

1-methyl-D-tryptophan (D-1MT) is a potent and selective indoleamine 2,3-dioxygenase (IDO) inhibitor with IC50 ~7 μM. It disrupts tryptophan catabolism and enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. It can reduce tumor volume in mice with xenografts overexpressing IDO.

How to Use:

In vitro: D-1MT was used at 10-50 μM final concentration in various in vitro assays.
In vivo: D-1MT was dosed at 5 mg/Kg orally to mice bearing A20 B-cell lymphoma.

Reference:

1. Rytelewski M, et al. Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. (2014) PLoS One. 9(2):e90439.?
2. Nakamura N, et al. Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. (2015) Int J Hematol. 102(3):327-34.?

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