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IWP-2,Porcupine(Wnt)Inhibitor

品牌：Xcessbio

貨號：M60115-2s

規(guī)格：2mg solid

貨期：

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IWP-2,Porcupine(Wnt)Inhibitor

商品詳情參考文獻(xiàn) 相關(guān)資料

Product Information

Molecular Weight:	466.60
Formula:	C₂₂H₁₈N₄O₂S₃
Purity:	≥98%
CAS#:	686770-61-6
Solubility:	DMSO up to 10 mM
Chemical Name:	N-(6-methylbenzo[d]thiazol-2-yl)-2-((4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

IWP-2 is a potent and highly selective Wnt signaling antagonist with an IC_50?~ 27 nM in the L-Wnt-STF cellular assay. It prevents palmitoylation of Wnt proteins by Porcupine (a membrane-bound O-acyltransferase), thereby blocking Wnt protein secretion and activity. It blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. IWP-2 is a useful chemical probe in both regenerative medicine and anticancer efforts.

How to Use:

In vitro:?IWP-2 was used at 1-2 μM in vitro and in cellular assays.
In vivo:?n/a

Reference:?

1. Chen B, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. (2009) Nat Chem Biol. 5(2):100-7.
2. ten Berge D, et al. Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. (2011) Nat Cell Biol. 13(9):1070-5.
3. Lian X, et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. (2012) Proc Natl Acad Sci USA. 109(27):E1848-57. ? ? ?

Products are for research use only. Not for human use.

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