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BAZ2-ICR,BAZ2BromodomainInhibitor
品牌：Xcessbio
貨號：M60226-2s
規(guī)格：2 mg solid
貨期：
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BAZ2-ICR,BAZ2BromodomainInhibitor
商品詳情 參考文獻 相關(guān)資料
Product Information
Molecular Weight: 357.41
Formula: C20H19N7
Purity: ≥98%
CAS#: n/a
Solubility: DMSO up to 100 mM
Chemical Name: 4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-5-yl)benzonitrile
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

Biological Activity:

BAZ2-ICR is a potent and selective BAZ2 bromodomain inhibitor with Kd values of 109 and 170 nM for BAZ2A and BAZ2B, respectively. It exhibits 15-fold selectivity for the BAZ2 bromodomain over the CERC2 bromodomain and >100-fold selectivity over a range of other bromodomains. It shows accelerated FRAP recovery at 1 μM in the BAZ2A FRAP assay.

How to Use:

In vitro:? BAZ2-ICR was used at 1-10 μM final concentration in various in vitro assays.

In vivo: n/a

Reference:

  • 1.????? http://www.thesgc.org/chemical-probe/BAZ2-ICR

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