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A potent inhibitor of GSK-3 (Glycogen synthase kinase-3) (IC= 30 nM). At 400 nM, TWS119 induces neurogenesis in murine embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.

Additional Information

Synonyms	3-[[6-(3-Aminophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol
Product #	G-2342
CAS #	601514-19-6
Chemical Name	3-[[6-(3-Aminophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol
Formula	C18H14N4O2
MW	318.33
Appearance	Slightly pink Solid
Purity	95% by HPLC
Solubility	Soluble in DMSO (20 mg/ml)
Storage Temp	-20°C
Use	A cell-permeable agent shown to act as a potent inhibitor of GSK-3β

Additional Information

MDL Number	MFCD09037535
ChemACX	X1755715-6
InChI	InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
SMILES	C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O