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GW501516
品牌：AG Scientific
貨號：
規(guī)格：1 mg
貨期：
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CAS:317318-70-0Formula:C21H18F3NO3S2MW:453.5Appearance:Whitetooff-whiteSolidPurity:98%byHPLC
商品詳情 參考文獻(xiàn) 相關(guān)資料

A selective agonist for PPAR (peroxisome proliferator-activated receptor) (EC= 1. 1 nM), displaying 1000-fold selectivity over the other human subtypes. In macrophages, fibroblasts, and intestinal cells, GW501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux.

Additional Information

Synonyms(2-Methyl-4-(((4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazol-5-yl)methyl)sulfanyl)phenoxy)acetic acid
Product #G-2348
CAS #317318-70-0
Chemical Name(2-Methyl-4-(((4-methyl-2-(4-trifluoromethylphenyl)-1,3-thiazol-5-yl)methyl)sulfanyl)phenoxy)acetic acid
FormulaC21H18F3NO3S2
MW453.5
AppearanceWhite to off-white Solid
Purity98% by HPLC
SolubilityDMSO (50 mg/ml) or EtOH (12 mg/ml)
Storage Temp-20°C
Therapeutic AreaEndocrinological Disorders
UseA selective and potent PPARβ agonist

Additional Information

MDL NumberMFCD09033000
ChemACXX1463059-2
InChIInChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
SMILESCC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O
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