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p300/CBP inhibitor, C-646

品牌：AG Scientific

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規(guī)格：1 mg

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CAS:328968-36-1Formula:C24H19N3O6MW:445.42Appearance:RedSolidPurity:98%byNMR

商品詳情參考文獻相關資料

Cell-permeable. A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor (K = 400 nM). Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (10%). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.

Additional Information

Synonyms	(E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid; C646, p300/CBP Inhibitor
Product #	C-2212
CAS #	328968-36-1
Chemical Name	(E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Formula	C₂₄H₁₉N₃O₆
MW	445.42
Appearance	Red Solid
Purity	98% by NMR
Solubility	DMSO (25 mM)
Storage Temp	-20°C
Use	C646 is a competitive histone acetyltransferase (HAT) p300/CBP inhibitor?use in cancer

Additional Information

MDL Number	MFCD01784780
ChemACX	X3304905-5
InChI	InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
SMILES	Cc1cc(c(cc1C)[N+](=O)[O-])c2ccc(o2)/C=C3/C(=NN(C3=O)c4ccc(cc4)C(=O)O)C

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