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Phenylhexyl Isothiocyanate
品牌:AG Scientific
貨號:
規(guī)格:25 mg
貨期:
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CAS:133920-06-6Formula:C13H17NSMW:219.35Appearance:ClearcolorlessliquidPurity:≥98%

商品詳情 參考文獻(xiàn) 相關(guān)資料

Isothiocyanates are compounds typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer chemotherapeutic, chemopreventive, anti-angiogenic, and antibiotic properties. In vitro, phenhexyl isothiocyanate (PHITC) increases caspase 3 activity and cleavage of poly(ADP)-ribose polymerase (PARP), inducing caspase-mediated apoptosis in cellular models. This compound decreases oxidation of carcinogen NNK and increases activity of NADPH:quinone oxidoreductase and glutathione S-transferase in vitro and in vivo. PHITC inhibits histone deacetylase (HDAC) activity, IL-6 receptor production, and VEGF expression; it also induces mitochondrial membrane depolarization and apoptosis in myeloma cells. In leukemia cells, PHITC inhibits expression of cyclin and increases expression of cyclin dependent kinase (CDK) inhibitors, inducing apoptosis and inhibiting growth of xenografts of these cells in animals.

Additional Information

Synonyms6-Phenylhexyl isothiocyanate; PHITC
Product #P-2951
CAS #133920-06-6
Chemical Name6-isothiocyanatohexylbenzene
FormulaC13H17NS
MW219.35
AppearanceClear colorless liquid
Purity≥98%
SolubilitySoluble in oraganic solvents.
Storage Temp-20°C

Additional Information

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