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Ligand with various binding profiles dependent on vanilloid receptors. Agonist at rat TRPV1 (ECbetween 3 and 10M), but reported to be inactive at human TRPV1 (EC10M). Induces apoptosis through a TRPV-independent mechanism.

Additional Information

Synonyms	Phorbol 12-phenylacetate 13-acetate 20 homovanillate
Product #	P-1095
CAS #	175796-50-6
Chemical Name	Phorbol 12-phenylacetate 13-acetate 20 homovanillate
Formula	C39H44O11
MW	688.8
Appearance	White Powder
Purity	95%
Solubility	Soluble in Water or DMSO
Storage Temp	+4°C
Therapeutic Area	Oncological Disorders
Use	PPAHV is a non-pungent resiniferatoxin-type phorboid vanilloid.PPAHV additionally induces apoptosis through a TRPV-independent mechanism and is a tumor promotor

Additional Information

MDL Number	MFCD06411584
ChemACX	X1009778-0
InChI	InChI=1S/C39H44O11/c1-21-14-30-37(45,34(21)44)19-26(20-48-31(42)18-25-12-13-28(41)29(16-25)47-6)15-27-33-36(4,5)39(33,50-23(3)40)35(22(2)38(27,30)46)49-32(43)17-24-10-8-7-9-11-24/h7-16,22,27,30,33,35,41,45-46H,17-20H2,1-6H3/t22-,27+,30-,33-,35-,37-,38-,39-/m1/s1
SMILES	C[C@@H]1[C@H]([C@@]2([C@@H](C2(C)C)[C@H]3[C@]1([C@@H]4C=C(C(=O)[C@]4(CC(=C3)COC(=O)Cc5ccc(c(c5)OC)O)O)C)O)OC(=O)C)OC(=O)Cc6ccccc6