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上海拜力生物科技公司
Tel:400-968-7988    021-33779008
Erlotinib Hydrochloride Salt
品牌：AG Scientific
貨號(hào)：
規(guī)格：100 mg
貨期：
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CAS:183319-69-9Formula:C22H23N3O4.HClMW:429.9Appearance:Whitetooff-whiteSolidPurity:99%byHPLC
商品詳情 參考文獻(xiàn) 相關(guān)資料

Erlotinib is an inhibitor of human Epidermal growth factor receptor (EGFR) tyrosine kinase (IC= 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC= 20 nM). Studies in cell lines and enzyme assays have both shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl.

Additional Information

SynonymsCP-358774, OSI-774
Product #E-2307
CAS #183319-69-9
Chemical NameN-(3-ETHYNYLPHENYL)-6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4-AMINE HYDROCHLORIDE
FormulaC22H23N3O4.HCl
MW429.9
AppearanceWhite to off-white Solid
Purity99% by HPLC
SolubilityDMSO
Melting Point223-225 °C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseAn HER-1/EGFR tyrosine kinase inhibitor used to treat non-small cell lung cancer (NSCLC), pancreatic cancer

Additional Information

MDL NumberMFCD07781272
ChemACXX1511913-0
InChIInChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
SMILESCOCCOc1cc2c(cc1OCCOC)ncnc2Nc3cccc(c3)C#C.Cl
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