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MetAP-2 inhibitor.Fumagillin is an inhibitor of endothelial cell proliferation and angiogenesis. Fumagillin is also being investigated as potential treatment of intestinal microsporidiosis.We investigated the role of fumagillin as a potential therapy in experimental Pulmonary Hypertension (PH). 1.Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents pulmonary hypertension in monocrotaline-injured rats.

Additional Information

Synonyms	Amebacilin, Fugillin, Fumidil B, Fumidil
Product #	F-1028
CAS #	23110-15-8
Chemical Name	10-[[5-METHOXY-4-[2-METHYL-3-(3-METHYLBUT-2-ENYL)OXIRAN-2-YL]-2-OXASPIRO[2.5]OCT-6-YL]OXY]-10-OXO-DECA-2,4,6,8-TETRAENOIC ACID
Formula	C26H34O7
MW	458.6
Appearance	White Powder
Purity	98%
Solubility	EtOH (10%)
Melting Point	194-195 °C
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	Fumagillin has been used in the treatment of microsporidiosis

Additional Information

MDL Number	MFCD03990453
ChemACX	X1009716-0
InChI	InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24+,25+,26+/m1/s1
SMILES	CC(=CC[C@@H]1[C@@](O1)(C)[C@@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)/C=C/C=C/C=C/C=C/C(=O)O)OC)C