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Cell-permeable. Acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC= 27 nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion.

Additional Information

Synonyms	N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Product #	I-2366
CAS #	686770-61-6
Chemical Name	N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Formula	C22H18N4O3S3
MW	466.6
Appearance	Beige Solid
Purity	98% by TLC
Solubility	DMSO (~5 mg/ml with warming)
Melting Point	316.82 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks β-catenin accumulation in gastric cancer.

Additional Information

MDL Number	MFCD12912418
ChemACX	X1763501-7
InChI	InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
SMILES	Cc1ccc2c(c1)sc(n2)NC(=O)CSc3nc4c(c(=O)n3c5ccccc5)SCC4