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MF-438, SCD1 inhibitor
品牌：AG Scientific
貨號(hào)：
規(guī)格：25 mg
貨期：
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CAS:921605-87-0Formula:C19H18F3N5OSMW:421.44Appearance:Off-whitesolidPurity:98%byHPLCNMR(Confirms)
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MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50= 2.3 nM.?MF-438 was potent in an?in vivo?mouse liver PD assay (ED50?between 1 and mg/kg).?Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.?MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.

Additional Information

Product #M-3329
CAS #921605-87-0
Chemical Name2-Methyl-5-(6-(4-(2-trifluoromethyl)phenoxy)piperidin-3-yl)-1,3,4-thiadiazole
FormulaC19H18F3N5OS
MW421.44
AppearanceOff-white solid
Purity98% by HPLC NMR (Confirms)
SolubilitySoluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
Storage Temp-20°

Additional Information

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