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Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.

Additional Information

Synonyms	XI-011
Product #	N-1215
CAS #	59474-01-0
Chemical Name	(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
Formula	C17H16N2S.HCl
MW	316.85
Appearance	Yellow Solid
Purity	98%
Solubility	Soluble in DMSO (100 mM) or EtOH (10 mM)
Storage Temp	Room Temp
Therapeutic Area	Oncological Disorders
Use	NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription

Additional Information

MDL Number	MFCD09878281
ChemACX	X1486529-7
InChI	InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H
SMILES	[H]/N=C(\[NH3+])/SCc1c2ccccc2c(c3c1cccc3)C.[Cl-]