98%(TLC)" />

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上海拜力生物科技公司
Tel:400-968-7988    021-33779008
Dorsomorphin Inhibit Myostatin / GDF8 Signaling, inhibits Bmp-Smad pathway
品牌：AG Scientific
貨號(hào)：
規(guī)格：5 mg
貨期：
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CAS:866405-64-3Formula:C24H25N5OMW:399.5Appearance:YellowSolidPurity:>98%(TLC)
商品詳情 參考文獻(xiàn) 相關(guān)資料

Cell-permeable. A potent, selective, reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki=109 nM in the presence of ATP and no AMP). Displays no significant inhibition of JAK3, PKA, PKCθ, SYK and ZAPK. Suppresses food intake in mice and inhibits the effects of AICAR and metformin.Also inhibits bone morphogenic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells. In addition, recently Dorsomorphin has shown to induce protective autophagy in cancer cells through AMPK inhibition-independent pathway.

Additional Information

SynonymsBML-275; Compound C; AMPK INHIBITOR
Product #D-1310
CAS #866405-64-3
Chemical Name6-[4-(2-Piperidin-1-yl)-ethoxy)- phenyl)]-3-pyridin-4-yl- pyrazolo[1,5-a]-pyrimidine
FormulaC24H25N5O
MW399.5
AppearanceYellow Solid
Purity>98%(TLC)
SolubilityMay be dissolved in DMSO (4 mg/ml, warm).
Melting Point244.93 °C
Storage TempStore desiccated at -20°C. Store solutions at -20°C for up to 3 months
Therapeutic AreaNeurological Disorders
UseA potent inhibitor of AMPK

Additional Information

MDL NumberMFCD08705402
ChemACXX1561649-0
InChIInChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
SMILESC1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3
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