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1,3-Diiscaropropylcarbodiimide?is a coupling agent often used widely in organic chemistry for the synthesis of amides, peptides, esters and various heterocycles.Carbodiimide based reagents have been routinely used in peptide chemistry for the formation of amide bonds since the introduction of dicyclohexylcarbodiimide (DCC) and its use in combination with the racemisation suppressing additive 1-hydroxybenzotriazole (HOBt )?and more recently 2-hydroxypyridine N-oxide (HOPO).

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