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A biotinylated derivative of the tetrapeptide inhibitor ASTD-FMK, which acts as a competitive inhibitor for the cleavage site of pro-EMAP II (Endothelial monocyte-activating polypeptide). EMAPII, which is a proinflammatory cytokine and a chemoattractant for monocytes, is specifically processed and released upon the induction of apoptosis in cultured cells.

Additional Information

Synonyms	Biotinyl-Ala-Ser-Thr-DL-Asp-Fluoromethylketone; Biotinyl-ASTD-Fluoromethylketone
Product #	B-2206
Chemical Name	Biotinyl-Ala-Ser-Thr-DL-Asp-Fluoromethylketone; Biotinyl-ASTD-Fluoromethylketone
Formula	C25H39FN6O10S
MW	634.68
Appearance	Yellow Solid
Purity	95% by HPLC
Solubility	DMSO
Storage Temp	-20°C

Additional Information

MDL Number	MFCD02684534
ChemACX	X1271602-4
InChI	InChI=1S/C25H39FN6O10S/c1-11(27-18(36)6-4-3-5-17-21-15(10-43-17)30-25(42)32-21)22(39)29-14(9-33)23(40)31-20(12(2)34)24(41)28-13(7-19(37)38)16(35)8-26/h11-15,17,20-21,33-34H,3-10H2,1-2H3,(H,27,36)(H,28,41)(H,29,39)(H,31,40)(H,37,38)(H2,30,32,42)/t11-,12+,13?,14?,15-,17-,20-,21-/m0/s1
SMILES	O=C1N[C@@H]2[C@H](CCCCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NC(CC(=O)O)C(=O)CF)[C@@H](C)O)SC[C@@H]2N1
Peptide Sequence	BIOTINYL-ALA-SER-THR-DL-ASP-FLUOROMETHYLKETONE