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A reversible and membrane-permeable blocker of IP3-mediated Ca2+ release. It does not interact with the IP3-.Also reported to block the increase in intracellular calcium in vascular smooth muscle cells completely at a concentration of 25 mM. Xestospongin C also inhibits the sarcoplasmic reticulum Ca2+ ATPase pump at concentrations of 700nM. This product is freely soluble in organic solvents such as chloroform, ethyl acetate, and methyl acetate and slightly soluble in DMSO and H2O.Serotonin modulates the population activity profile of olfactory bulb external tufted cells.Mitochondrial Reactive Oxygen Species Are Activated by mGluR5 through IP3 and Activate ERK and PKA to Increase Excitability of Amygdala Neurons and Pain Behaviorf.Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress andCell Death.Glucose and Endoplasmic Reticulum Calcium Channels Regulate HIF. Presenilin in PancreaticCells.

Additional Information

Synonyms	XeC, Araguspongine E
Product #	X-1009
CAS #	88903-69-9
Chemical Name	1R- (1R*,4aR*,11R*,12aS*,13S*,16aS*,23R*,24aS*)]- eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H- [1,11]dioxacycloeicosino[2,3-b:12,13-b1]dipyridine
Formula	C28H50N2O2
MW	446.7
Appearance	White to Off-White Solid (may appears as clear film on vial)
Purity	90%
Solubility	Soluble in DMSO or 0.1 N NaOH.
Storage Temp	-20°C

Additional Information

MDL Number	MFCD01862629
ChemACX	X1277713-6
InChI	InChI=1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m0/s1
SMILES	C1CCC[C@H]2CCN3CCC[C@@H]([C@H]3O2)CCCCCC[C@H]4CCN5CCC[C@H]([C@H]5O4)CC1