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IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Murine IP-10 is an 8.7 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines.

Source: E.coli

Synonyms: γ-Interferon Inducible Protein-10, CXCL10, crg-2

AA Sequence: IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Assay #1:Determined by its ability to chemoattract IL-2 activated T cells using a concentration range of 0.1-10.0 ng/ml.
Assay #2: Determined by its ability to chemoattract CXCR3-transfected HEK293 cells using a concentration range of 100-500 ng/ml.