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Biotin - anti mouse CD169 - Clone 3D6
品牌：Immunostep
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Biotin - anti mouse CD169 - Clone 3D6
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Biotin - anti Mouse CD169 - 3D6

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63,00 € tax excl.

104,00 € tax excl.

Product Description

  • 3D6
  • Rat IgG2a
  • Flow Cytometry
  • Biotin
  • 0.5 mg/ml
  • Purified Native Sialoadhesin from spleen
  • Mouse
  • The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
  • RUO
  • CD169, clone 3D6, is a mAb intended for RUO in the identification/enumeration of lymph that express CD169. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 μg/106 cells.
  • Liquid
  • Store in the dark at 2-8 °C
Mouse PU-PP-B Vial View larger
CD169, also known as Siglec-1 and Sialoadhesin (Sn), is a type I lectin containing 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains). CD169 binds to sialic acids, which can be found on PSGL-1, CD43, CD206, and CD227. By its affinity to ?2, 3-linked sialic acid, it is involved in macrophage binding to different cell types such as granulocytes, monocytes, NK, B, and T cells. CD169 was initially identified as a sialic acid-dependent sheep erythrocyte receptor (SER) on resident bone marrow cells of mice. It has been identified as highly expressed on resident bone marrow macrophages which plays an important role in retention of stem cells in mesenchymal stem cell niche. It is also found on some specific subsets of tissue macrophages in spleen, lymph nodes, bone marrow, liver, colon, lungs, and cancer cells. Evidence suggest that CD169-positive macrophages serve as lymph node-resident APCs to dominate early activation of tumor antigen-specific CD8+ T cells and invariant NK cell.
  • Sialic acid binding Ig-like lectin 1 (Siglec-1), Sialoadhesin (Sn)
  • 20612
  • 183 kD
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