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DiscoverX PI3-Kinase (p110alpha(H1047R) p85alpha) 14-792M
品牌：Eurofins DiscoverX
貨號：14-792M
規(guī)格：14-792M
貨期：DiscoverX
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品牌：DiscoverX 品名：PI3-Kinase (p110α(H1047R)/p85α) 貨號：14-792M 規(guī)格：250 μg
商品詳情 參考文獻(xiàn) 相關(guān)資料
品牌：DiscoverX
品名：PI3-Kinase (p110α(H1047R)/p85α)
貨號：14-792M      

規(guī)格：250 μg



簡要說明：


PI3-Kinase (p110α(H1047R)/p85α)

Complex of N-terminal 6His-tagged recombinant, human p110α full length, containing the mutation H1047R, and untagged recombinant, human p85α full length. The H1047R substitution is a somatic mutation in p110α that has been associated with tumours of the colon, stomach, breast and brain. Combined in vitro and in vitro studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Samuels Y. et al., Science, (2004); 304: 554; Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).


產(chǎn)品介紹：



Target
PI3Kα/p85α
Expression System
Expressed by baculovirus in Sf21 insect cells
Application
Kinase Assay
Molecular Weight
125 kDa (p110α H1047R), 84 kDa (p85α)
Accession Number
U79143
Species
Human
Tag
6His
Purification Method
Ni2+/NTA-agarose
Content
Protein in 50mM Tris/HCl pH8.0, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
Storage
6 months at -70°C
Bulk Sizes
Inquire


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