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DiscoverX JAK1, active 14-918M

品牌：Eurofins DiscoverX

貨號：14-918M

規(guī)格：14-918M

貨期：DiscoverX

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品牌：DiscoverX 品名：JAK1, active 貨號：14-918M 規(guī)格：250 μg

商品詳情參考文獻相關(guān)資料

品牌：DiscoverX
品名：JAK1, active
貨號：14-918M
規(guī)格：250 μg

簡要說明：

JAK1, active

N-terminal GST-tagged recombinant, human JAK1 amino acids 866-end. Activated in vitro by auto-phosphorylation. Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-α/beta and -γ signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-α pathway, and between JAK1 and JAK2 in the interferon-γ pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

產(chǎn)品介紹：

Target

JAK1

Expression System

Expressed by baculovirus in Sf21 insect cells

Application

Kinase Assay

Molecular Weight

61 kDa

Accession Number

NM_002227

Species

Human

Tag

GST

Purification Method

Glutathione Sepharose? affinity chromatography

Content

Protein in 50mM Tris/HCl pH7.5, 150mM NaCl, 5mM β-glycerophosphate, 0.5mM sodium orthovanadate, 50% v/v glycerol, 0.02% Triton® X-100, 0.5mM EDTA, 2mM DTT. Frozen solution.

Storage

6 months at -70°C

Bulk Sizes

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